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Nobel Prize in Chemistry 2018

Post by Admin Oct 04,2018

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Nobel Prize in Chemistry 2018

Post by Admin,Oct 04,2018.
News

What is in news

The three researchers(Frances Arnold of the California Institute of Technology, George Smith of the University of Missouri,Gregory Winter of the MRC Laboratory of Molecular Biology in Cambridge) who were awarded this year's Nobel Prize in chemistry "harnessed the power of evolution" to develop enzymes and antibodies that have led to new pharmaceuticals and biofuels. They were honoured for "phage display  of peptides and antibodies.

Background

The Nobel Prize in Chemistry is awarded annually by the Royal Swedish Academy of Sciences to scientists in the various fields of chemistry. It is one of the five Nobel Prizes established by the 1895 will of Alfred Nobel, who died in 1896. These prizes are awarded for outstanding contributions in chemistry, physicsliteraturepeace, and physiology or medicine. As dictated by Nobel's will, the award is administered by the Nobel Foundation and awarded by a committee that consists of five members elected by the Royal Swedish Academy of Sciences

About the Invention

The power of evolution is revealed through the diversity of life. The 2018 Nobel Laureates in Chemistry have taken control of evolution and used it for purposes that bring the greatest benefit to humankind. Enzymes produced through directed evolution are used to manufacture everything from biofuels to pharmaceuticals. Antibodies evolved using a method called phage display can combat autoimmune diseases and in some cases cure metastatic cancer.

This year's Nobel Laureates in Chemistry have been inspired by the power of evolution and used the same principles -- genetic change and selection -- to develop proteins that solve humankind's chemical problems.

One half of this year's Nobel Prize in Chemistry is awarded to Frances H. Arnold. In 1993, she conducted the first directed evolution of enzymes, which are proteins that catalyse chemical reactions. Since then, she has refined the methods that are now routinely used to develop new catalysts. The uses of Frances Arnold's enzymes include more environmentally friendly manufacturing of chemical substances, such as pharmaceuticals, and the production of renewable fuels for a greener transport sector.

The other half of this year's Nobel Prize in Chemistry is shared by George P. Smith and Sir Gregory P. Winter. In 1985, George Smith developed an elegant method known as phage display, where a bacteriophage -- a virus that infects bacteria -- can be used to evolve new proteins. Gregory Winter used phage display for the directed evolution of antibodies, with the aim of producing new pharmaceuticals. The first one based on this method, adalimumab, was approved in 2002 and is used for rheumatoid arthritis, psoriasis and inflammatory bowel diseases. Since then, phage display has produced anti-bodies that can neutralise toxins, counteract autoimmune diseases and cure metastatic cancer.